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The Anticonvulsant Effects of Progesterone, its Metabolites, and 5α-Dihydroprogesterone Novel Analogs in Amygdala-kindled Seizures in Rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhong, Muyuan |
| Copyright Year | 2015 |
| Abstract | ..................................................................................................................... ii ACKNOWLEDGEMENTS ............................................................................................. iii TABLE OF CONTENTS ................................................................................................. v LIST OF TABLES ............................................................................................................ ix LIST OF FIGURES .......................................................................................................... x LIST OF ABBREVIATIONS .......................................................................................... xi CHAPTER 1: General Introduction ............................................................................... 1 1.1 Epilepsy .............................................................................................................. 2 1.1.1 Definitions .............................................................................................. 2 1.1.2 Epidemiology and Onset of Epilepsy ..................................................... 2 1.1.3 Classification Based on Etiology ............................................................ 3 1.1.4 The Comorbidities and the Psychosocial Problems ................................ 3 1.1.5 Treatment: Pharmacotherapy – Successes and Drawbacks ..................... 4 1.2 Seizures ............................................................................................................... 5 1.2.1 Definitions .............................................................................................. 5 1.2.2 Common Seizure Types .......................................................................... 8 1.3 Complex Partial Seizures .................................................................................. 8 1.3.1 Definitions .............................................................................................. 8 1.3.2 Intractability ............................................................................................ 11 1.4 The Kindling Model .......................................................................................... 11 1.4.1 Definitions .............................................................................................. 11 1.4.2 Advantages .............................................................................................. 12 1.4.3 The Amygdala Kindling Model .............................................................. 12 1.5 The Reproductive Cycle in Female Rats ......................................................... 13 1.5.1 The Estrous Cycle ................................................................................... 13 1.5.2 Kindling Effect on the Estrous Cycle ..................................................... 14 1.6 Progesterone ....................................................................................................... 15 1.6.1 Background ............................................................................................. 15 1.6.2 The Synthetic Pathway ........................................................................... 17 1.7 Past Studies: The Anticonvulsant Effects of Progesterone ........................... 19 1.7.1 Clinical Observations/Studies ................................................................ 19 1.7.2 Animal Studies ....................................................................................... 21 1.8 Progesterone Metabolism and Metabolites .................................................... 23 1.9 The Anticonvulsant Effects of Progesterone Metabolites ............................. 25 1.9.1 Indirect Evidence from the Progesterone Studies .................................. 25 1.9.2 Direct Evidence from the 5α-DHP and THP Studies ............................. 25 1.10 5α-DHP as a Promising AED for Complex Partial Epilepsies .................... 28 1.11 Objectives of the Present Study ..................................................................... 28 1.12 Research Hypothesis ....................................................................................... 29 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://tspace.library.utoronto.ca/bitstream/1807/70777/3/Zhong_Muyuan_201511_MSc_thesis.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
