NDLI: Synthesis and Characterization of Polysialic Acid/carboxymethyl Chitosan Hydrogel with Potential for Drug Delivery

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Synthesis and Characterization of Polysialic Acid/carboxymethyl Chitosan Hydrogel with Potential for Drug Delivery

Content Provider	Semantic Scholar
Author	Zhan, Xiao Bei Zheng, Zhi Yong Zhang, Hai Tang
Copyright Year	2015
Abstract	Polysialic acid (PSA) is a negatively charged ho mopolymer of α 2,8 linked sialic acids (N acytyl neuraminic acid) found at the N glycan terminal of neural cell adhesion molecule (NCAM) [1]. PSA can be easily produced in large scale setups by fermenta tion with Escherichia coli [2] and presents great poten tial in biomedical applications. PSA exhibits prospec tive use as a biomaterial because of its biodegradability, biocompatibility, and non immunogenicity [3]. Certain pathogenic bacteria, such as Neisseria meningitis, E. coli K1, Haemophilus ducreyi, and Pasteurella heamolytica, can synthesize PSA, and the polysaccharide can help these pathogens escape from mammalian immunolog ical recognition and killing through mimicking the host’s cellular oligosaccharides [4]. Based on this ob servation, Gregoriadis et al. [5] developed a polysialy lation method for modifying therapeutic proteins to improve protein pharmacokinetics and stability. Sev eral groups have employed this technology to modify catalase [6], asparaginase [7, 8], insulin [9], CuZn su peroxide dismutase [10], and butyrylcholinesterase
File Format	PDF HTM / HTML
DOI	10.7868/s0132342315040132
Alternate Webpage(s)	http://www.rjbc.ru/2015/5/2015_41_5(627-632).pdf
Alternate Webpage(s)	https://doi.org/10.7868/s0132342315040132
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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