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Synthesis and characterization of amphiphatic carboxymethyl-hexanoyl chitosan hydrogel: water-retention ability and drug encapsulation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liu, Tse-Ying Chen, San-Yuan Lin, Yi-Ling |
| Copyright Year | 2006 |
| Abstract | Carboxymethyl-hexanoyl chitosan (NOCHC) amphiphatic hydrogel with excellent water-absorption and water-retention abilities under neutral conditions was successfully synthesized for the first time and then employed as a carrier for delivering amphiphatic agents. NOCHC is a water-soluble chitosan derivative bearing the carboxymethyl (hydrophilic) group and the hexanoyl (hydrophobic) group, which was synthesized using N,O-carboxymethyl chitosan (NOCC) as the starting precursor. Water-absorption ability (W(c)), water-retention ability, and drug encapsulation efficiency of the NOCHC hydrogel were investigated in terms of the degree of carboxymethyl and hexanoyl substitution. It was found that the amount of moisture uptake was dependent on the relative humidity as well as degree and nature of such substitution. The hexanoyl substitution affected significantly the water-absorption ability by altering the number of water-binding sites and the state of water under low humidity and the fully swollen state, respectively. In addition, the presence of hydrophobic hexanoyl substitution significantly retards water mobility during deswelling, causing better water-retention ability. Moreover, compared with that of pristine chitosan and NOCC, the encapsulation efficiency of ibuprofen (partially hydrophobic agent) was significantly enhanced with the incorporation of the hexanoyl group. These results demonstrate that the newly developed NOCHC amphiphatic hydrogel showed enhanced water-absorption ability, water-retention ability, and amphiphatic drug encapsulation efficiency compared with NOCC and chitosan. |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/la061471n |
| PubMed reference number | 17073505 |
| Journal | Medline |
| Volume Number | 22 |
| Issue Number | 23 |
| Alternate Webpage(s) | https://ir.nctu.edu.tw/bitstream/11536/11558/1/000241669800043.pdf |
| Alternate Webpage(s) | https://doi.org/10.1021/la061471n |
| Journal | Langmuir : the ACS journal of surfaces and colloids |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
