NDLI: Cell proliferation in rat colon measured with bromodeoxyuridine, proliferating cell nuclear antigen, and [3H]thymidine.

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Cell proliferation in rat colon measured with bromodeoxyuridine, proliferating cell nuclear antigen, and [3H]thymidine.

Content Provider	Semantic Scholar
Author	Richter, Friedrich Richter, Andrea Yang, Kunhua Lipkin, Martin
Copyright Year	1992
Abstract	Epithelial cell proliferation was studied in the normal colonic mucosa of 5-week-old Sprague-Dawley rats, comparing [3H]thymidine incorporation (group 1) with two newer proliferation markers, bromodeoxyuridine (group 2) and proliferating cell nuclear antigen (group 3). Microautoradiography (group 1) or immunoperoxidase assays (groups 2 and 3) were carried out. Cells were counted for positive reaction and position along 50 colonic crypt columns/animal. No significant differences were found in number or distribution of labeled epithelial cells in proliferative compartments in crypt columns of normal colonic mucosa; labeled cells were mainly in the lower 60% of colonic crypts. Thus, in this model, bromodeoxyuridine and proliferating cell nuclear antigens were comparable to [3H]thymidine as reliable markers of proliferating epithelial cells in rat colon.
File Format	PDF HTM / HTML
PubMed reference number	1363835
Journal	Medline
Volume Number	1
Issue Number	7
Alternate Webpage(s)	http://cebp.aacrjournals.org/content/cebp/1/7/561.full.pdf
Alternate Webpage(s)	http://cebp.aacrjournals.org/content/cebp/1/7/561.full.pdf?origin=publication_detail
Journal	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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