NDLI: Long-term IL-1β exposure causes subpopulation-dependent alterations in rat dorsal root ganglion neuron excitability.

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Long-term IL-1β exposure causes subpopulation-dependent alterations in rat dorsal root ganglion neuron excitability.

Content Provider	Semantic Scholar
Author	Stemkowski, Patrick L. Smith, Peter Anthony
Copyright Year	2012
Abstract	The effect of interleukin-1β (IL-1β) on the electrical properties of sensory neurons was assessed at levels and exposure times comparable to those found in animal models of neuropathic pain. Experiments involved whole cell current-clamp recordings from rat dorsal root ganglion (DRG) neurons in defined-medium, neuron-enriched cultures. Five- to six-day exposure to 100 pM IL-1β produced subpopulation-dependent effects on DRG neurons. These included an increase in the excitability of medium-diameter and small-diameter isolectin B(4) (IB(4))-positive neurons that was comparable to that found after peripheral nerve injury. By contrast, a reduction in excitability was observed in large-diameter neurons, while no effect was found in small-diameter IB(4)-negative neurons. Further characterization of changes in medium and small IB(4)-positive neurons revealed that some, but not all, effects of IL-1β were mediated through its receptor, IL-1RI. Although the acute actions of IL-1β on sensory neurons have been well studied and related to acute and/or inflammatory pain, the present study shows how sensory neurons respond to long-term cytokine exposure. Such effects are relevant to understanding processes that contribute to the onset of neuropathic pain.
Starting Page	3981
Ending Page	3992
Page Count	12
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jn.physiology.org/content/jn/early/2011/12/09/jn.00587.2011.full.pdf
PubMed reference number	22170966v1
Alternate Webpage(s)	https://doi.org/10.1152/jn.00587.2011
DOI	10.1152/jn.00587.2011
Journal	Journal of neurophysiology
Volume Number	107
Issue Number	6
Language	English
Access Restriction	Open
Subject Keyword	Afferent neuron Animal Model Diameter (qualifier value) Ganglia, Spinal Griffonia simplicifolia isolectin B4 Isolectins Neuralgia Neurons Pain Peripheral Nerve Injuries Peripheral Nerves Posterior root of spinal nerve cytokine nerve injury
Content Type	Text
Resource Type	Article

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