NDLI: Establishment of a live vaccine strain against fowl typhoid and paratyphoid

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Establishment of a live vaccine strain against fowl typhoid and paratyphoid

Content Provider	Semantic Scholar
Author	Cho, Sun-Hee Ahn, Young-Jin Kim, Tae-Eun Kim, Sun-Joong Huh, Won Moon, Young-Sik Lee, Brittney Kim, Jae-Hong Kwon, Hyuk Joon
Copyright Year	2016
Abstract	To develop a live vaccine strain against fowl typhoid and paratyphoid caused by Salmonella serovar Gallinarum biovar Gallinarum (Salmonella Gallinarum) and Salmonella serovar Enteritidis (Salmonella Enteritidis), respectively, several nalidixic acid resistant mutants were selected from lipopolysaccharide (LPS) rough strains of Salmonella Gallinarum that escaped from fatal infection of a LPS-binding lytic bacteriophage. A non-virulent and immunogenic vaccine strain of Salmonella Gallinarum, SR2-N6, was established through in vivo pathogenicity and protection efficacy tests. SR2-N6 was highly protective against Salmonella Gallinarum and Salmonella Enteritidis and safer than Salmonella Gallinarum vaccine strain SG 9R in the condition of protein-energy malnutrition. Thus, SR2N6 may be a safe and efficacious vaccine strain to prevent both fowl typhoid and paratyphoid.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://kjvr.org/upload/2016/01/05/20160105094931234310.pdf
Language	English
Access Restriction	Open
Subject Keyword	Bacteriophages Consent Type - Typhoid Lightweight Portable Security Lipopolysaccharides Lysis Nalidixic Acid Paratyphoid Fever Protein-Energy Malnutrition Salmonella enterica subsp. enterica serovar enteritidis Salmonella gallinarum Salmonella infections Serotype SuicideGirls Typhoid Fever Vaccines, Attenuated Video-in video-out
Content Type	Text
Resource Type	Article

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