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Characterization of a T7-like lytic bacteriophage (phiSG-JL2) of Salmonella enterica serovar gallinarum biovar gallinarum.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kwon, Hyuk-Joon Cho, Sun-Hee Kim, Tae-Eun Won, Yong-Jin Jeong, Ji‐hye Park, Se Chang Kim, Jae-hong Yoo, Han Sang Park, Yong-ho Kim, Sun-Joong |
| Copyright Year | 2008 |
| Abstract | PhiSG-JL2 is a newly discovered lytic bacteriophage infecting Salmonella enterica serovar Gallinarum biovar Gallinarum but is nonlytic to a rough vaccine strain of serovar Gallinarum biovar Gallinarum (SG-9R), S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Gallinarum biovar Pullorum. The phiSG-JL2 genome is 38,815 bp in length (GC content, 50.9%; 230-bp-long direct terminal repeats), and 55 putative genes may be transcribed from the same strand. Functions were assigned to 30 genes based on high amino acid similarity to known proteins. Most of the expected proteins except tail fiber (31.9%) and the overall organization of the genomes were similar to those of yersiniophage phiYeO3-12. phiSG-JL2 could be classified as a new T7-like virus and represents the first serovar Gallinarum biovar Gallinarum phage genome to be sequenced. On the basis of intraspecific ratios of nonsynonymous to synonymous nucleotide changes (Pi[a]/Pi[s]), gene 2 encoding the host RNA polymerase inhibitor displayed Darwinian positive selection. Pretreatment of chickens with phiSG-JL2 before intratracheal challenge with wild-type serovar Gallinarum biovar Gallinarum protected most birds from fowl typhoid. Therefore, phiSG-JL2 may be useful for the differentiation of serovar Gallinarum biovar Gallinarum from other Salmonella serotypes, prophylactic application in fowl typhoid control, and understanding of the vertical evolution of T7-like viruses. |
| Starting Page | 125701 |
| Ending Page | 125701 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://aem.asm.org/content/74/22/6970.full.pdf |
| Alternate Webpage(s) | http://dspace.ewha.ac.kr/bitstream/2015.oak/232926/1/characterization.pdf |
| PubMed reference number | 18820072v1 |
| Alternate Webpage(s) | https://doi.org/10.1128/AEM.01088-08 |
| DOI | 10.1128/aem.01088-08 |
| Journal | Applied and environmental microbiology |
| Volume Number | 74 |
| Issue Number | 22 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amino Acids Bacteriophages Classification Condoms, Unspecified Genome Gordonia sp. CC-JL2-2 Lysis Nucleotides PersonNameUse - assigned Salmonella enterica subsp. enterica serovar enteritidis Salmonella infections Salmonella phage phiSG-JL2 Salmonella pullorum Ab:ACnc:Pt:Ser:Qn Serotype Terminal Repeat Sequences Tissue fiber Typhoid Fever |
| Content Type | Text |
| Resource Type | Article |
