Loading...
Please wait, while we are loading the content...
Similar Documents
Altered levels of cyclic nucleotides, cyclic AMP phosphodiesterase and adenylyl cyclase activities in normal, dysplastic and neoplastic human mammary tissue.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kueng, Willy Bechtel, E. Geyer, Egbert Salokangas, A. A. Preisz, J. Huber, Philippe Torhorst, Joachim Jungmann, Richard A. Talmadge, Karen Eppenberger, Urs |
| Copyright Year | 1977 |
| Abstract | Recently, we have reported decreased cellular levels of CAMP-dependent protein kinase and CAMP-binding activity in neoplastic human mammary tissue [l] . Considering the sensitivity of the CAMP-protein kinase system to changes of CAMP, it was important to determine intracellular levels of this cyclic nucleotide and to identify changes of phosphodiesterase and adenylyl cyclase activities, the two enzyme systems which directly regulate the intracellular CAMP metabolism. Recently, increased levels of CAMP were reported in human mammary carcinomas [2] . Our results show that neoplastic mammary tissues exhibit increased specific levels but decreased cellulsr levels of CAMP and cGMP. In addition, the cellular activities of adenylyl cyclase phosphodiesterase are significantly lower in neoplastic as compared with normal human breast tissues. |
| Starting Page | 485 |
| Ending Page | 485 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://eurekamag.com/ftxt.php?pdf=000286459 |
| PubMed reference number | 199454v1 |
| Volume Number | 82 |
| Issue Number | 1 |
| Journal | FEBS letters |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 8-chloro-cyclic adenosine monophosphate Adenylate Cyclase Animal Mammary Neoplasms Body tissue Carcinoma Cyclic AMP Cyclic GMP Mammary Carcinoma, Human Mammary Gland Parenchyma Nucleotides Nucleotides, Cyclic Protein Kinases abnormal cellular structure or growth |
| Content Type | Text |
| Resource Type | Article |
