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A comparison of in vivo 13C MR brain glycogen quantification at 9.4 and 14.1 T.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Heeswijk, Ruud B. Van Pilloud, Yves Morgenthaler, Florence D. Gruetter, Rolf |
| Copyright Year | 2012 |
| Abstract | The high molecular weight and low concentration of brain glycogen render its noninvasive quantification challenging. Therefore, the precision increase of the quantification by localized (13) C MR at 9.4 to 14.1 T was investigated. Signal-to-noise ratio increased by 66%, slightly offset by a T(1) increase of 332 ± 15 to 521 ± 34 ms. Isotopic enrichment after long-term (13) C administration was comparable (≈ 40%) as was the nominal linewidth of glycogen C1 (≈ 50 Hz). Among the factors that contributed to the 66% observed increase in signal-to-noise ratio, the T(1) relaxation time impacted the effective signal-to-noise ratio by only 10% at a repetition time = 1 s. The signal-to-noise ratio increase together with the larger spectral dispersion at 14.1 T resulted in a better defined baseline, which allowed for more accurate fitting. Quantified glycogen concentrations were 5.8 ± 0.9 mM at 9.4 T and 6.0 ± 0.4 mM at 14.1 T; the decreased standard deviation demonstrates the compounded effect of increased magnetization and improved baseline on the precision of glycogen quantification. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 22223461 |
| Journal | Medline |
| Volume Number | 67 |
| Issue Number | 6 |
| Alternate Webpage(s) | https://infoscience.epfl.ch/record/177434/files/ruud_mrm_glyc_14T.pdf |
| Alternate Webpage(s) | https://serval.unil.ch/resource/serval:BIB_ACE27F8EF4D8.P001/REF |
| Alternate Webpage(s) | https://doi.org/10.1002/mrm.23192 |
| Journal | Magnetic resonance in medicine |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
