NDLI: Localized in vivo 13 C MRS of brain glycogen at 9 . 4 and 14 . 1 T : a comparison

Content Provider	Semantic Scholar
Author	Heeswijk, Ruud B. Van Pilloud, Yves Morgenthaler, Florence D. Gruetter, Rolf
Copyright Year	2009
Abstract	Introduction Glycogen (Glyc) is the main energy store in the brain, but its precise metabolic role remains to be fully elucidated [1]. Currently, the only method to study brain glycogen non-invasively in vivo is C NMR together with C label incorporation through a substrate such as [1-C] glucose (Glc). Nevertheless, this method remains challenging and time consuming, not only due to the low amount of signal per unit of time, but also due to the broad line shape of the glycogen resonances. The main cause of this detection challenge are its short T1 and T2 relaxation times (on the order of a few hundred and 5-10 ms respectively), caused by its branched polysaccharide structure. The aim of this study was to follow the improvement of the Glyc C1 resonance with a magnetic field strength B0 increase from 9.4 to 14.1 T, and to compare it to the adjacent Glc C1β resonance. Since the Glyc T1 relaxation time is known to increase proportionally with B0 [2,3] and might have an influence on the signal-to-noise ratio (SNR) at short relaxation times, it was also determined at both field strengths.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://cds.ismrm.org/protected/10MProceedings/files/3323_3671.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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