NDLI: Molecular regulation of cardiomyocyte differentiation.

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Molecular regulation of cardiomyocyte differentiation.

Content Provider	Semantic Scholar
Author	Paige, Sharon L. Plonowska, Karolina A. Xu, Adele F. Wu, Sean M.
Copyright Year	2015
Abstract	The heart is the first organ to form during embryonic development. Given the complex nature of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital heart disease is present in ≈1 percent of newborns. The molecular determinants of heart development have received much attention over the past several decades. This has been driven in large part by an interest in understanding the causes of congenital heart disease coupled with the potential of using knowledge from developmental biology to generate functional cells and tissues that could be used for regenerative medicine purposes. In this review, we highlight the critical signaling pathways and transcription factor networks that regulate cardiomyocyte lineage specification in both in vivo and in vitro models. Special focus will be given to epigenetic regulators that drive the commitment of cardiomyogenic cells from nascent mesoderm and their differentiation into chamber-specific myocytes, as well as regulation of myocardial trabeculation.
Starting Page	243
Ending Page	254
Page Count	12
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circres.ahajournals.org/content/circresaha/116/2/341.full.pdf?download=true
PubMed reference number	25593278v1
Alternate Webpage(s)	https://doi.org/10.1161/CIRCRESAHA.116.302752
DOI	10.1161/circresaha.116.302752
Journal	Circulation research
Volume Number	116
Issue Number	2
Language	English
Access Restriction	Open
Subject Keyword	Body tissue Cardiomyopathies Cell Differentiation process Congenital heart disease Embryonic Development Heart Diseases Infant, Newborn Language Development Disorders Mesoderm Morphogenesis Muscle Cells Myocytes, Cardiac Regenerative Medicine Specification TRANSCRIPTION FACTOR cardiac muscle cell differentiation cardiocyte differentiation heart development study of epigenetics trabecula formation
Content Type	Text
Resource Type	Article

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