NDLI: Frontal white matter anisotropy and symptom severity of late-life depression: a magnetic resonance diffusion tensor imaging study.

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Frontal white matter anisotropy and symptom severity of late-life depression: a magnetic resonance diffusion tensor imaging study.

Content Provider	Semantic Scholar
Author	Nobuhara, Kenji Okugawa, Gaku Sugimoto, Toru Minami, Tomohisa Tamagaki, Chiharu Takase, Katsunori Saito, Yukinobu Sawada, Satoshi Kinoshita, Toshibumi
Copyright Year	2006
Abstract	OBJECTIVES To investigate the disruption of neural circuits in the frontal lobes and limbic structures in late-life depressed patients compared with healthy controls, and to examine the correlation between the degree of microstructural abnormalities of white matter and clinical symptom severity in late-life depression. METHODS Thirteen patients with late-life depression and matched control subjects underwent diffusion tensor imaging. Fractional anisotropy (FA), an index of the integrity of white matter tracts, was determined in the white matter of frontal, temporal, and occipital brain regions and the corpus callosum. RESULTS A significant reduction was found in white matter FA values of widespread regions of the frontal and temporal lobes of depressed patients. Also, there was some evidence suggesting that white matter FA values of the inferior frontal brain region are inversely related to severity of depression. CONCLUSIONS These results suggest the possible loss of integrity within frontal and temporal white matter fibre tracts and implicate the orbitofrontal circuit in symptom severity in late-life depression.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jnnp.bmj.com/content/jnnp/77/1/120.full.pdf?77/1/120=
Alternate Webpage(s)	http://jnnp.bmj.com/content/jnnp/77/1/120.full.pdf?legid=jnnp%3B77/1/120
Alternate Webpage(s)	http://jnnp.bmj.com/content/jnnp/77/1/120.full.pdf
PubMed reference number	16361611v1
Volume Number	77
Issue Number	1
Journal	Journal of neurology, neurosurgery, and psychiatry
Language	English
Access Restriction	Open
Subject Keyword	Anisotropy Body of uterus Congenital Abnormality Corpus Callosum Depressive disorder Diffusion Tensor Imaging Patients Temporal Lobe White matter frontal lobe
Content Type	Text
Resource Type	Article

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