NDLI: The White Matter Microintegrity Alterations of Neocortical and Limbic Association Fibers in Major Depressive Disorder and Panic Disorder

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The White Matter Microintegrity Alterations of Neocortical and Limbic Association Fibers in Major Depressive Disorder and Panic Disorder

Content Provider	Semantic Scholar
Author	Lai, Chien-Han Wu, Yu-Te
Copyright Year	2016
Abstract	The studies regarding to the comparisons between major depressive disorder (MDD) and panic disorder (PD) in the microintegrity of white matter (WM) are uncommon. Therefore, we tried to a way to classify the MDD and PD. Fifty-three patients with 1st-episode medication-naive PD, 54 healthy controls, and 53 patients with 1st-episode medication-naive MDD were enrolled in this study. The controls and patients were matched for age, gender, education, and handedness. The diffusion tensor imaging scanning was also performed. The WM microintegrity was analyzed and compared between 3 groups of participants (ANOVA analysis) with age and gender as covariates. The MDD group had lower WM microintegrity than the PD group in the left anterior thalamic radiation, left uncinate fasciculus, left inferior fronto-occipital fasciculus, and bilateral corpus callosum. The MDD group had reductions in the microintegrity when compared to controls in the bilateral superior longitudinal fasciculi, inferior longitudinal fasciculi, inferior fronto-occipital fasciculi, and corpus callosum. The PD group had lower microintegrity in bilateral superior longitudinal fasciculi and left inferior fronto-occipital fasciculus when compared to controls. The widespread pattern of microintegrity alterations in fronto-limbic WM circuit for MDD was different from restrictive pattern of alterations for PD.
Starting Page	791
Ending Page	800
Page Count	10
File Format	PDF HTM / HTML
PubMed reference number	26945417v1
Alternate Webpage(s)	https://doi.org/10.1097/MD.0000000000002982
DOI	10.1097/md.0000000000002982
Journal	Medicine
Volume Number	95
Language	English
Access Restriction	Open
Subject Keyword	Body of uterus Corpus Callosum Diffusion Tensor Imaging Fascicle - nerve fibers Handedness Limbic Encephalitis Major Depressive Disorder Panic Disorder Patients Thalamic structure Therapeutic radiology procedure White matter
Content Type	Text
Resource Type	Article

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