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Synthesis and anti-HIV activity of N'-nicotinoyl--3-(4'-hydroxy-3'-methylphenyl)-5-[substituted phenyl]-2-pyrazolines.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ali, Mohamed Ashraf Yar, M. Shahar Siddiqui, Anees A. Sriram, Dharmarajan Yogeeswari, Perumal Clercq, Erick De |
| Copyright Year | 2007 |
| Abstract | A series of N'-nicotinoyl-3-(4'-hydroxy-3'-methylphenyl)-5-(substituted phenyl)-2-pyrazolines were synthesized by the reaction between isoniazid (INH) and chalcones and were tested for their in vitro anti-HIV activity. Among them, compound (c) showed a promising anti-HIV activity in vitro against used strains (IIIB, ROD), with IC50 of both IIIB 5.7 microM and ROD 7.0 microM. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 18540162 |
| Journal | Medline |
| Volume Number | 64 |
| Issue Number | 5 |
| Alternate Webpage(s) | http://ptfarm.pl/pub/File/Acta_Poloniae/2007/5/423.pdf |
| Journal | Acta poloniae pharmaceutica |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |