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New Novel Synthesis and Antibacterial Activity of 1-(Substituted phenyl)-2- phenyl-4-(3'-halo, 4'-hydroxy 5'-methoxy benzylidene)-imidazole-5-ones
| Content Provider | Semantic Scholar |
|---|---|
| Author | Siddiqui, Shafi A. Bhusare, Sudhakar R. Jarikote, Dilip Venkatrao Pawar, Rajendra P. Vibhute, Yeshwant B. |
| Copyright Year | 2001 |
| Abstract | Benzylidene derivatives are also re-ported to possess anticonvulsant and MAO inhibitory activity.This observation prompted us to synthesize new 1-(sub-stituted phenyl)-2-phenyl-4-(3'-iodo/bromo, 4'-hydroxy, 5'-methoxy benzylidene)-imidazole-5-one by a new methodand evaluate their antimicrobial activity.Early the imidazolones (4) have been prepared by heatinga mixture of 5-oxazolone derivatives (3) with aromatic andsubstituted aromatic amines in presence of pyridine for 10-15 hours. The yield of the imidazolones (4) was very poorand the reaction was a long time reaction. In the context of studies we have introduced some newimidazolone (4), synthesized by the condensation of aromaticand substituted aromatic amines with 5-oxazolone derivative(3) in presence of (Y-H) Zeolite (Scheme 1). The reactiontakes place in 3-5 hours with excellent yield. The 5-oxa-zolone derivatives (ozalactone) are prepared by the conden-sation of hippuric acid with 5-bromo/iodo-4-hydroxy-3-methoxy benzaldehyde in presence of sodium acetate andacetic anhydride. The compounds were crystallized from alcohol. The pro-ducts have been identified on the basis of elemental analysisand spectral data (Table 1).Antibacterial activity. The synthesized compounds werescreened for their antimicrobial activity using EscherischiaColi (EC), Azotobacteria (AZ) Bacillus subtillis (BS) Sal-monella typhi (ST) and Salmonella dysentrae (SD) bacteria. |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/chin.200216138 |
| Volume Number | 33 |
| Alternate Webpage(s) | http://pdf.easechem.com/pdf/32/97a35b4b-a89b-47bf-85a1-7efdfdc4507e.pdf |
| Alternate Webpage(s) | https://doi.org/10.1002/chin.200216138 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |