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Hepatitis viruses in Ethiopia: a systematic review and meta-analysis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Belyhun, Yeshambel Maier, Melanie Mulu, Andargachew Diro, Ermias Liebert, Uwe G. |
| Copyright Year | 2016 |
| Abstract | BACKGROUND The existing seroepidemiological data on viral hepatitis in Ethiopia showed a wide variation in prevalence pattern and the clinical and public health burden have been underestimated. The aim of this systematic review and meta-analysis was to provide a clear and comprehensive estimation of viral hepatitis epidemiology and the potential clinical burdens in Ethiopia. METHODS A comprehensive literature search was carried out from five decades (1968-2015) published studies from biomedical databases; PubMed, Google scholar, Medline and Web of Science. RESULTS The overall pooled prevalence of hepatitis B virus (HBV) was 7.4% (95%CI: 6.5-8.4). The pooled prevalence among subgroups showed 5.2% (95%CI: 3.7-7.4) in human immunodeficiency virus (HIV) infected individuals, 8.0% (95%CI: 5.9-10.7) in community based studies, 8.4% (95%CI: 5.4-12.7) in blood donors, 11.0% (95%CI: 7.5-15.9) in immigrants and 6.9% (95%CI: 5.6-8.5) in other groups. Among study parameters considered during meta-regression analysis, only study years were associated with a decreasing HBV prevalence rate over time. The overall pooled prevalence of anti-hepatitis C virus antibody (anti-HCV) was 3.1% (95%CI: 2.2-4.4). Unlike HBV, the anti-HCV prevalence in HIV infected individuals was higher (5.5%, 95%CI: 3.8-7.8%, p = 0.01) than the prevalence observed in the other subgroup of study population. Although relatively few data were available, hepatitis virus A (HAV), D (HDV) and E (HEV) were also circulated in Ethiopia. CONCLUSIONS This review indicates that all types of viral hepatitis origins are endemic in Ethiopia. Adapting a recommended diagnostic and treatment algorithm of viral hepatitis in the routine healthcare systems and implementing prevention and control policies in the general population needs an urgent attention. |
| Starting Page | 1040 |
| Ending Page | 1045 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://bmcinfectdis.biomedcentral.com/track/pdf/10.1186/s12879-016-2090-1 |
| PubMed reference number | 27993129v1 |
| Volume Number | 16 |
| Journal | BMC infectious diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Chemical and Drug Induced Liver Injury HIV Infections Hematological Disease Hepatitis B Virus Hepatitis C virus Hepatitis Delta Virus Hepatitis E virus Hepatitis Viruses Herpesvirus 1, Cercopithecine Immunologic Deficiency Syndromes National origin Pooled Sample Review, Systematic Scientific Publication Subgroup A Nepoviruses Viral hepatitis |
| Content Type | Text |
| Resource Type | Article |
