NDLI: Hepatitis B virus infection and the risk of nonalcoholic fatty liver disease: a meta-analysis

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Hepatitis B virus infection and the risk of nonalcoholic fatty liver disease: a meta-analysis

Content Provider	Semantic Scholar
Author	Xiong, Jianping Zhang, Haoaohai Wang, Yaqin Wang, Anqiang Bian, Jin Huang, Hanchun Zheng, Ying Sang, Xinting Xu, Yiyao Lu, Xin Zhao, Haitao
Copyright Year	2017
Abstract	Some studies have reported that hepatitis B virus (HBV) infection affects the risk of nonalcoholic fatty liver disease (NAFLD). However, this association is controversial. We conducted a systematic review and meta-analysis to investigate the relationship between HBV infection and NAFLD. Relevant studies published before May 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. We used the random-effects model proposed by DerSimonian and Laird to quantify the relationship between HBV infection and risk of NAFLD. We also conducted subgroup and sensitivity analyses to validate the stability of the results. Five articles, comprising 8,272 HBV-infected patients and 111,631 uninfected controls, were included in our research. Our meta-analysis suggested that the risk of NAFLD was significantly lower in HBV-infected patients than in uninfected controls, with heterogeneity between studies (summary odds ratio [OR] = 0.71; confidence interval [CI] = 0.53-0.90; I2 = 75.2%). However, the inverse relationship was observed in only cohort (OR = 0.83; 95% CI = 0.73-0.94) and cross-sectional studies (OR = 0.63; 95% CI = 0.47-0.79), not case-control studies (OR = 3.96; 95% CI = 2.10-7.48). In conclusion, HBV infection was inversely associated with the risk of NAFLD.
Starting Page	107295
Ending Page	107302
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=22364&path%5B%5D=70754
PubMed reference number	5739814
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.22364
DOI	10.18632/oncotarget.22364
Journal	Oncotarget
Volume Number	8
Language	English
Access Restriction	Open
Subject Keyword	Chemical and Drug Induced Liver Injury Confidence Intervals Cross-Sectional Studies Hepatitis B Virus Herpesvirus 1, Cercopithecine Liver diseases Non-alcoholic Fatty Liver Disease Patients Scientific Publication Subgroup A Nepoviruses
Content Type	Text
Resource Type	Article

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