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Universidade Federal De Santa Catarina - Ufsc Centro De Ciências Da Saúde - Ccs Programa De Pós Graduação Em Farmácia - Pgfar
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ribeiro, Carine Muniz |
| Copyright Year | 2009 |
| Abstract | Effect of benznidazole treatment and antioxidant therapy in chagasic chronic cardiopaty There is evidence to suggest that chagasic myocardial patients are exposed to oxidative stress that contributes to the disease progression. Benzonidazole (BZN) is the only etiologic treatment available in Brazil and its action involves the covalent modification of parasite macromolecules by reactive species generated during the nitroreductor drug metabolism. However, beside to its tripanocide mechanism, its metabolism generates de deleterious oxidative effects in the host. The present study is a sequence of related publications on the same subjects, who showed an increased oxidative stress associated with the severity of the disease (OLIVEIRA et al., 2007), which was attenuated by supplementation of vitamins E and C (MACAO et al., 2007). The objective of the present study was to evaluate the effect of antioxidant supplementation with vitamins E (800 UI/day) and C (500 mg/day) during six months, after BZN therapy (5 mg/Kg/day) during two months, in order to minimize the deleterious effects that this therapy promotes in the host. Patients were classified and divided according to the modified Los Andes clinical hemodynamic classification, in groups IA (n=10), IB (n=20), II (n=7) and III (n=4). The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione Stransferase (GST) and glutathione reductase (GR), as well as the contents of reduced glutathione (GSH), vitamin E and C, biomarkers of oxidative stress such as thiobarbituric acid reactive species (TBARS) and protein carbonyls (PC), and the inflammatory markers myeloperoxidase (MPO), nitric oxide (NO) and adenosine deaminase (ADA), were all determined in the blood of patients. Comparisons among the different chagasic groups were carried out by ANOVA, with post hoc analysis using the Tukey test, and the Student t-test was used to compare each chagasic group before and after the treatments. The results revealed that after two months of BZN treatment the antioxidant enzymes activities of GPx were enhanced in all groups: IA (p=0.0004), IB (p<0.0001), II (p=0.0087) and III (p=0.0008); the enzymes SOD in groups IA (p<0.0001), IB (p=0.0007) and II (p=0.0087), CAT IA (p=0.0390), IB (p=0.0001) and II (p=0.0068) and GST IA (p<0.0001), IB (p<0.0001) and II (p=0.0090) were enhanced in all groups, except in group III; PC levels were elevated in all groups, IA (p=0.0046), IB (p=0.0025) and II (p=0.0041), except in group III; |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://repositorio.ufsc.br/bitstream/handle/123456789/92447/266561.pdf?isAllowed=y&sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
