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Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sepetov, Nikolai F. Krchňák, Viktor Staňková, Magda Wade, S. Lebl, Michal |
| Copyright Year | 1995 |
| Abstract | Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-beta-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 7777524 |
| Journal | Medline |
| Volume Number | 92 |
| Issue Number | 12 |
| Alternate Webpage(s) | http://www.pnas.org/content/92/12/5426.full.pdf%3Fck=nck |
| Alternate Webpage(s) | https://doi.org/10.1073/pnas.92.12.5426 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |