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Structure-Based Combinatorial Library Design and Screening: Application of the Multiple Copy Simultaneous Search Method
| Content Provider | Scilit |
|---|---|
| Author | Joseph-McCarthy, Diane |
| Copyright Year | 2001 |
| Description | Recent advances in combinatorial chemistry have dramatically increased the number of new compounds that can be synthesized (1,2). While high throughput robotic methods (3) have accelerated the process of screening large corporate databases and combinatorial libraries, it is still not possible to experimentally screen all available compounds. As a result, there is a critical need for new computational methods for designing, constructing, and screening virtual libraries. This includes methods for designing diverse libraries as well as those for designing focused libraries for specific targets or for computationally screening diverse libraries for binding to a specific target. Book Name: Combinatorial Library Design and Evaluation |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2006-0-18374-8&isbn=9780429180972&doi=10.1201/9781482270761-23&format=pdf |
| Ending Page | 550 |
| Page Count | 28 |
| Starting Page | 523 |
| DOI | 10.1201/9781482270761-23 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2001-06-26 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Combinatorial Library Design and Evaluation Medicinal Chemistry Combinatorial Libraries Specific Target Diverse Libraries Methods for Designing |
| Content Type | Text |
| Resource Type | Chapter |
