NDLI: Real-time, subsecond, multicomponent breath analysis by Optical Parametric Oscillator based Off-Axis Integrated Cavity Output Spectroscopy.

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Real-time, subsecond, multicomponent breath analysis by Optical Parametric Oscillator based Off-Axis Integrated Cavity Output Spectroscopy.

Content Provider	Semantic Scholar
Author	Arslanov, Denis D. Swinkels, Koen R. Cristescu, Simona M. Harren, Frans J. M.
Copyright Year	2011
Abstract	Breath analysis is an attractive field of research, due to its high potential for non-invasive medical diagnostics. Among others, laser-based absorption spectroscopy is an excellent method for the detection of gases in exhaled breath, because it can combine a high sensitivity with a good selectivity, and a high temporal resolution. Here, we use a fast-scanning continuous wave, singly-resonant Optical Parametric Oscillator (wavelength range between 3 and 4 μm, linewidth 40 MHz, output power > 1 W, scanning speed 100 THz/s) with Off-Axis Integrated Cavity Output Spectroscopy for rapid and sensitive trace gas detection. Real-time, low- ppbv detection of ethane is demonstrated in exhaled human breath during free exhalations. Also, simultaneous, real-time multi-component gas detection of ethane, methane and water was performed in exhaled breath using a wide spectral coverage over 17 cm(-1) in 1 second. Furthermore, real-time detection of acetone, a molecule with a wide absorption spectrum, was shown in exhaled breath, with a sub-second time resolution (0.4 s).
File Format	PDF HTM / HTML
PubMed reference number	22109433
Journal	Medline
Volume Number	19
Issue Number	24
Alternate Webpage(s)	https://repository.ubn.ru.nl/bitstream/handle/2066/92259/92259.pdf?sequence=1
Alternate Webpage(s)	http://repository.ubn.ru.nl/bitstream/handle/2066/92259/92259.pdf?sequence=1
Alternate Webpage(s)	https://www.ru.nl/publish/pages/792895/real-time_subsecond_multicomponent_breath_analysis_by_optical_parametric_oscillator_based_off-axis_integrated_cavity_output_spectroscopy.pdf
Alternate Webpage(s)	https://doi.org/10.1364/OE.19.024078
Journal	Optics express
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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