NDLI: Heparin-induced thrombocytopenia associated with thrombotic microangiopathy.

Please wait, while we are loading the content...

Heparin-induced thrombocytopenia associated with thrombotic microangiopathy.

Content Provider	Semantic Scholar
Author	Studt, J-D Binet, Isabelle Nair, Govind Schanz, Urs
Copyright Year	2013
Abstract	Some cases of thrombotic microangiopathy (TMA) are refractory to plasma exchange therapy (PE) with persistence or recurrence of thrombocytopenia. We report two patients suffering from TMA of different aetiologies (associated with disseminated malignancy, typical haemolytic uraemic syndrome) with recurrent or persistent thrombocytopenia despite adequate therapy including PE. Since both patients were exposed to unfractionated heparin, heparin-induced thrombocytopenia (HIT) was suspected as a cause. Pretest probabilities for HIT were intermediate. ELISA for PF4/heparin antibodies was strongly positive in both cases, and HIT was confirmed by heparin-induced platelet activation assay. Anticoagulation with lepirudin was initiated, with subsequent rapid increase of the platelet count. TMA might represent a predisposition for HIT. This could be due to TMA-related platelet activation with increased PF4 release. In TMA patients exposed to heparin and with refractory or rapidly recurrent thrombocytopenia HIT should always be considered as a possible cause.
Starting Page	77
Ending Page	79
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://haemo.schattauer.de/en/contents/archive/issue/1747/manuscript/19728/download.html
Alternate Webpage(s)	https://research.kssg.ch/EXPORT/PDF/Publikation/56613.pdf
PubMed reference number	23715106v1
Alternate Webpage(s)	https://doi.org/10.5482/HAMO-13-03-0012
DOI	10.5482/hamo-13-03-0012
Journal	Hamostaseologie
Volume Number	33
Issue Number	2
Language	English
Access Restriction	Open
Subject Keyword	Blood Platelet Disorders Hemolytic-Uremic Syndrome Heparin-induced thrombocytopenia Neoplasms Patients Plasmapheresis Platelet Count measurement Probability Thrombotic Microangiopathies heparin lepirudin
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Heparin-induced thrombocytopenia occurring after discontinuation of heparin.

Resolution of thrombotic microangiopathy following renal transplant.

Breast Cancer-Associated Thrombotic Microangiopathy.

Relative incidence of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome in clinically suspected cases of thrombotic microangiopathy

Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome associated with clopidogrel: report of two new cases.

Postoperative Atypical Hemolytic Uremic Syndrome in a 67-Year-Old Woman Associated with Hemolytic Anemia, Thrombocytopenia, and Acute Renal Failure.

Anti-glomerular basement membrane glomerulonephritis complicated by thrombocytopenia.

Severe sepsis caused by Capnocytophaga canimorsus complicated by thrombotic microangiopathy in an immunocompetent patient

Thrombotic microangiopathies: An illustrated review

Heparin-induced thrombocytopenia associated with thrombotic microangiopathy.

Similar Documents

Heparin-induced thrombocytopenia occurring after discontinuation of heparin.

Resolution of thrombotic microangiopathy following renal transplant.

Breast Cancer-Associated Thrombotic Microangiopathy.

Relative incidence of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome in clinically suspected cases of thrombotic microangiopathy

Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome associated with clopidogrel: report of two new cases.

Postoperative Atypical Hemolytic Uremic Syndrome in a 67-Year-Old Woman Associated with Hemolytic Anemia, Thrombocytopenia, and Acute Renal Failure.

Anti-glomerular basement membrane glomerulonephritis complicated by thrombocytopenia.

Severe sepsis caused by Capnocytophaga canimorsus complicated by thrombotic microangiopathy in an immunocompetent patient

Thrombotic microangiopathies: An illustrated review

Heparin-induced thrombocytopenia associated with thrombotic microangiopathy.