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Resolution of thrombotic microangiopathy following renal transplant.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Heemskerk, Laura Scott-Douglas, Nairn Yilmaz, Serdar McLaughlin, Kevin |
| Copyright Year | 2005 |
| Abstract | Thrombotic microangiopathy (TMA) is characterized by aggregation of platelets in the renal and/or systemic circulation, thrombocytopenia and intravascular haemolysis. TMA is well recognized in the setting of renal transplantation and has been attributed to a variety of aetiologies such as recurrence of original disease, use of calcineurin inhibitors, acute rejection and viral infections [1,2]. Thrombotic thrombocytopenic purpura (TTP) and haemolytic uraemic syndrome (HUS) represent the two most frequently encountered clinical presentations of TMA. There is considerable overlap in the clinical features of HUS and TTP and it is often difficult to distinguish between these entities. Moreover, in the setting of renal transplantation, both entities have been described, suggesting that the same underlying mechanism may result in TTP in some individuals and HUS in others [1]. The commonality between these syndromes makes it tempting to lump them together into the single entity of TMA. There are, however, important differences in the underlying disease mechanisms that may have prognostic and therapeutic implications, particularly in the setting of renal transplantation [3]. |
| Starting Page | 532 |
| Ending Page | 535 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/ndt/20/3/10.1093/ndt/gfh590/2/gfh590.pdf?Expires=1492049077&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=E4ov7IvT0iEEdYUdJ5Au~HaWwwIuEkv6F6fx~t1RJRa-L5TyPiBk2Akxg-4V6qhN1ey4pNg~mIdIUTTiJlZXVvW7ra3UlPLpYGDIIlmzOyijqhch9KaDL0PgOKrX-K5eeqad20HCN0c88L2gwRKHI3S7nyC6kURO6rnvsDlUE5FLKnUav6XtQmgjJa5sSc9uNZQBoZ-kcLH6fPoRi4T-c7iw6-teH35NWyUK-1JzOjt~U~XLq8lLTCmkfp2viVLUEYFFa1~UlNV6Ffu3zVmJ6rU7R2Z4jXWjWfMmSk6J~kFwUMnuNNpB1cda4pPgKxRvSXiXpyGQpziEZRy4peEFzA__ |
| PubMed reference number | 15735247v1 |
| Volume Number | 20 |
| Issue Number | 3 |
| Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Calcineurin inhibitor Deny (action) Hemolysis (disorder) Hemolytic-Uremic Syndrome Henoch-Schoenlein Purpura Intravascular hemolysis Kidney Transplantation Platelet Count measurement Purpura, Thrombotic Thrombocytopenic Thrombocytopenia Thrombotic Microangiopathies Virus Diseases |
| Content Type | Text |
| Resource Type | Article |
