NDLI: Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses

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Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses

Content Provider	Semantic Scholar
Author	Huber, B. Devinsky, Orrin Cantor, Harvey
Copyright Year	1976
Abstract	Cell-mediated immunity includes both the generation of cytotoxic cells and initiation of delayed-type hypersensitivity (DTH). The resting T-cell population, before stimulation by antigen, already contains cells of the Lyl subclass that are programmed to initiate DTH (and helper function) but not cytotoxic responses, as well as Ly23 cells which can generate killer activity (and suppressive function) but not DTH. The central implication of these findings is that the broad division between humoral and cell-mediated immune responses does not precisely correspond to the division of labor among T-cell subclasses. The relative contribution of DTH-competent Lyl cells and cytotoxic Ly23 cells to the classical homograft response remains to be determined.
Starting Page	1534
Ending Page	1539
Page Count	6
File Format	PDF HTM / HTML
PubMed reference number	1083891
Volume Number	143
Journal	The Journal of experimental medicine
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/e9/je14361534.PMC2190218.pdf
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/6c/e9/je14361534.PMC2190218.pdf
Language	English
Access Restriction	Open
Subject Keyword	Cellular Immunity Cellular Phone Delayed Hypersensitivity Drug Allergy Immune System Diseases Interphase Cell Leukemia, B-Cell T-Lymphocyte Transcription Initiation Transplantation, Homologous killer activity subclass
Content Type	Text
Resource Type	Article

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