NDLI: Cell-mediated immunity and its application in toxicology.

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Cell-mediated immunity and its application in toxicology.

Content Provider	Semantic Scholar
Author	Luster, Michael I. Dean, Jack H. Boorman, Gary A.
Copyright Year	1982
Abstract	A variety of in vivo and more recently in vitro assays have been described to assess cell mediated immunity (CMI). Two methods routinely employed in our laboratory to assess CMI following exposure to chemicals in rodents include delayed hypersensitivity and in vitro lymphoproliferation. Preliminary studies indicate that depressed delayed hypersensitivity responses, as performed by a radiometric assay, correlates with altered susceptibility to infectious agents and tumor cell challenge following exposure to immunotoxic chemicals. Furthermore, suppression of T-cell lymphoproliferative responses to at least 50% below control values correlated with depressed delayed hypersensitivity responses and altered host susceptibility. On the other hand, when suppression of T-cell lymphoproliferative responses are within 50% of control values, delayed hypersensitivity and host susceptibility parameters are not affected. Assuming adequate technical expertise and accurate data interpretation, CMI assays of these types can provide a valuable data base for toxicology studies and immunotoxicity assessment.
Starting Page	31
Ending Page	36
Page Count	6
File Format	PDF HTM / HTML
PubMed reference number	7037387v1
Volume Number	43
Journal	Environmental health perspectives
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/e6/81/envhper00460-0033.PMC1568880.pdf
Language	English
Access Restriction	Open
Subject Keyword	Cellular Immunity Cellular Phone Delayed Hypersensitivity Depressive disorder Diagnostic Service Section ID - Toxicology Drug Allergy In Vitro [Publication Type] Leukemia, B-Cell Neoplasms Other Toxicity Studies: Immunotoxicity Rodent infectious agent
Content Type	Text
Resource Type	Article

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