NDLI: New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system.

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New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system.

Content Provider	Semantic Scholar
Author	Johnson, Rick J. Couser, William G. Chi, Emil Y. Adler, S. Klebanoff, Seymour J.
Copyright Year	1987
Abstract	Reactive oxygen species, particularly hydrogen peroxide (H2O2), participate in neutrophil-mediated glomerulonephritis. However, the mechanism of H2O2 neptrotoxicity is unknown. Myeloperoxidase (MPO), a neutrophil cationic enzyme that localizes in glomeruli, can react with H2O2 and halides to form highly reactive products. We tested the hypothesis that the MPO-H2O2-halide system may induce glomerular injury by infusing MPO followed by H2O2 in a chloride-containing solution into the renal artery of rats. Controls received MPO or H2O2 alone. MPO-H2O2-perfused rats developed significant proteinuria, endothelial cell swelling, and epithelial cell foot process effacement, whereas control kidneys were normal. In the presence of free 125I, MPO-H2O2-perfused rats incorporated large amounts of 125I, localized to the glomerular basement membrane and mesangium by autoradiography, into glomeruli. Glomerular iodination was greatly decreased or absent in controls. The MPO-H2O2-halide system causes glomerular injury and may be important in neutrophil-mediated glomerulonephritis.
File Format	PDF HTM / HTML
DOI	10.1172/JCI112965
PubMed reference number	3033023
Journal	Medline
Volume Number	79
Issue Number	5
Alternate Webpage(s)	https://dm5migu4zj3pb.cloudfront.net/manuscripts/112000/112965/cache/112965.1-20150304082811-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/112000/112965/JCI87112965.pdf
Alternate Webpage(s)	https://doi.org/10.1172/JCI112965
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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