Journal of Leukocyte Biology 36:545-548 (1984) SHORT COMMUNICATION The Iron-Hydrogen Peroxide-Iodide System Is Fungicidal: Activity Against the Yeast Phase of Blastomyces dermatitidis (1984)

Content Provider	CiteSeerX
Author	Stevens, David A. Brummer, Elmer Chahal, Resham S. Sugar, Alan M.
Abstract	A series of experiments show the potency of a newly described microbicidal system, involving iron, H202, and halide, in killing a fungus (Blastomyces dermatitidis). B dermatitidis has previously been shown susceptible to the myeloperoxidase-H202-halide system. The present studies show killing of either of two strains in 1 hour if Fe + at 5 x 105M, H202 at 5 x 105M and KI at 5 x 104M are all present (P < 0.001). EDTA, a Fe + chelator, abrogates killing. The mechanism presumably utilizes hydroxyl radical, since an inhibitor, ethanol, also neutralizes the system. The bactericidal and fungicidal system is of great potential importance in vivo. Key words: fungal killing, oxidative metabolism, iron, hydroxyl radical The potent microbicidal activity of the myeloperoxidase-hydrogen peroxide-halide system has been extensively documented [3,5,7]. In addition to its bactericidal activity, both fungicidal and tumonicidal capabilities have been found [3,4,8,9]. More recently, Klebanoff has extended his original observations to include another bacteri-cidal system that is dependent on both hydrogen peroxide and a halide [6]. In this
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Publisher Date	1984-01-01
Access Restriction	Open
Subject Keyword	Fungicidal System Fe Chelator Bactericidal Activity Yeast Phase Hydrogen Peroxide Blastomyces Dermatitidis Iron-hydrogen Peroxide-iodide System Fungal Killing Utilizes Hydroxyl Radical Tumonicidal Capability Myeloperoxidase-h202-halide System Original Observation Leukocyte Biology Potent Microbicidal Activity Bacteri-cidal System Great Potential Importance Oxidative Metabolism Myeloperoxidase-hydrogen Peroxide-halide System Microbicidal System Short Communication
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