NDLI: Tetrahydroxystilbene glucoside inhibits α-synuclein aggregation and apoptosis in A53T α-synuclein-transfected cells exposed to MPP.

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Tetrahydroxystilbene glucoside inhibits α-synuclein aggregation and apoptosis in A53T α-synuclein-transfected cells exposed to MPP.

Content Provider	Semantic Scholar
Author	Zhang, Ruyi Sun, Fangling Zhang, Lan Sun, Xuejing
Copyright Year	2017
Abstract	Increasing evidence has solidified the involvement of α-synuclein (α-Syn) and neurotoxins in the pathogenesis of Parkinson's disease (PD), suggesting a combination of genetic and environmental influences. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) is one of the main active components extracted from Polygonum multiflorum. The purpose of the present study was to investigate the effects of TSG on α-Syn aggregation, mitochondrial dysfunction, oxidative stress, and apoptosis in vitro. A53T mutant α-synuclein-transfected cells (A53T AS cells) plus MPP+ exposure were used as a complex cell model of PD. The expression of proteins was determined by Western blot assay. Flow cytometry was utilized to measure mitochondrial membrane potential and apoptosis. The results showed that MPP+ exposure for 24 h induced more severe damage in A53T AS cells than in vector control cells. Pretreatment of TSG for 24 h significantly increased the cell viability; decreased lactate dehydrogenase leakage; inhibited α-Syn over-expression and aggregation; elevated mitochondrial membrane potential; decreased reactive oxygen species, Bax/Bcl-2 ratio, and caspase-3 activity; and inhibited apoptosis in A53T AS cells exposed to MPP+. These results suggest that TSG may be an attractive candidate for PD therapy.
Starting Page	750
Ending Page	758
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1139/cjpp-2016-0209
PubMed reference number	28187263
Journal	Medline
Volume Number	95
Issue Number	6
Alternate Webpage(s)	https://tspace.library.utoronto.ca/bitstream/1807/77176/1/cjpp-2016-0209.pdf
Alternate Webpage(s)	https://doi.org/10.1139/cjpp-2016-0209
Journal	Canadian journal of physiology and pharmacology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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