NDLI: Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation

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Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation

Content Provider	Semantic Scholar
Author	Li, Xiaobing Chen, Jianzong Sun, Jing Kang, Xiaogang
Copyright Year	2010
Abstract	It is known that oxidative stress plays a major role in the progression of Parkinson's disease (PD). Previous studies have suggested that 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (TSG), an active component extracted from a traditional Chinese herb Polygonum multiflorum Thunb., has significant antioxidant and free radical-scavenging activities. This is the first study that investigated the protective effects of TSG against MPP(+)-induced apoptosis in PC12 cells and determined the underlying mechanism. The results showed that incubation of PC12 cells with TSG before exposing them to MPP(+) could significantly decrease cell viability loss and reverse cell apoptosis in a dose-dependent manner. The anti-apoptotic effects of TSG were probably mediated via the inhibition of ROS generation and modulation of JNK activation because TSG blocked ROS increase and JNK phosphorylation induced by MPP(+). Taken together, these results indicated that TSG may provide a useful therapeutic strategy for the treatment of neurodegenerative diseases such as PD.
Starting Page	1
Ending Page	5
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/j.neulet.2010.07.027
PubMed reference number	20643188
Journal	Medline
Volume Number	483
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0304394010009286
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0304394010009286?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.neulet.2010.07.027
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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