NDLI: A comparison of the potency of newly developed oximes (K347, K628) and currently available oximes (obidoxime, HI-6) to counteract acute neurotoxic effects of Tabun in rats.

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A comparison of the potency of newly developed oximes (K347, K628) and currently available oximes (obidoxime, HI-6) to counteract acute neurotoxic effects of Tabun in rats.

Content Provider	Semantic Scholar
Author	Kassa, Jiří Karasová, Jana Zdárová Tesařová, Sandra Musilek, Kamil Kuča, Kamil
Copyright Year	2010
Abstract	The ability of newly developed oximes (K347, K628) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with currently available oximes (obidoxime, HI-6) using a functional observational battery. The neuroprotective effects of the oximes studied (K347, K628, obidoxime, HI-6) combined with atropine on rats poisoned with tabun at a sublethal dose (220 microg/kg i.m.; 80% of LD50 value) were evaluated. Tabun-induced neurotoxicity was monitored by a functional observational battery and automatic measurement of motor activity at 24 hours following tabun challenge. The results indicate that all tested oximes combined with atropine enable tabun-poisoned rats to survive 24 hours following tabun challenge. Both newly developed oximes (K347, K628) combined with atropine are able to decrease tabun-induced neurotoxicity in the case of sublethal poisonings but they do not eliminate all tabun-induced acute neurotoxic signs and symptoms. Their ability to decrease the tabun-induced acute neurotoxicity is higher than that of the oxime HI-6 and it is slightly slower than the neuroprotective efficacy of obidoxime. As the neuroprotective potency of both newly developed oximes (K347, K628) is not as high as the potency of obidoxime, they are not a suitable replacement for obidoxime for the treatment of acute tabun poisonings.
Starting Page	85
Ending Page	91
Page Count	7
File Format	PDF HTM / HTML
DOI	10.14712/18059694.2016.65
PubMed reference number	20672744
Journal	Medline
Volume Number	53
Issue Number	2
Alternate Webpage(s)	https://actamedica.lfhk.cuni.cz/media/pdf/am_2010053020085.pdf
Alternate Webpage(s)	https://doi.org/10.14712/18059694.2016.65
Journal	Acta medica
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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