NDLI: A comparison of the neuroprotective efficacy of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats.

Content Provider	Semantic Scholar
Author	Kassa, Jiří Karasová, Jana Zd'árová Tesařová, Sandra Kuča, Kamil Musilek, Kamil
Copyright Year	2008
Abstract	The neuroprotective effects of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with cyclosarin were studied. The cyclosarin-induced neurotoxicity was monitored using a functional observational battery 24 hours after cyclosarin challenge. The results indicate that a newly developed oxime K156 is able to counteract slightly cyclosarin-induced neurotoxicity while another newly developed oxime K203 is completely ineffective in reducing cyclosarin-induced neurotoxic signs and symptoms. The neuroprotective efficacy of K156 is comparable with commonly used obidoxime and oxime HI-6. Thus, none of the newly developed oximes achieves better neuroprotective efficacy than both commonly used oximes. They are therefore not suitable replacements for antidotal treatment of acute poisonings with cyclosarin.
File Format	PDF HTM / HTML
PubMed reference number	19453087
Journal	Medline
Volume Number	51
Issue Number	4
Alternate Webpage(s)	https://actamedica.lfhk.cuni.cz/media/pdf/am_2008051040215.pdf
Journal	Acta medica
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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