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Synthesis of Some New 1 , 3 , 4-Oxadiazole Derivatives Containing Azo Group from 5-[ 4-( p-Methoxyphenyl ) azophenyl ]-2-thiol-1 , 3 , 4 – oxadiozole
| Content Provider | Semantic Scholar |
|---|---|
| Author | Abood, Zaid Hassan Haiwal, Rahman Tama Abbas, Sawsan Khdeaur Radhi, Sajid Maksad Hameem, Rabab K. |
| Copyright Year | 2012 |
| Abstract | In this paper , the synthesis of 1,3,4-Oxadiazole derivatives containing azo group were achieved from 5-[4( P-methoxyphenyl ) azo phenyl ]-2thiol-1,3,4-Oxadiazole [4].Treatment of compound [4] with ethyl 1chloroacetate in alcoholic potassium hydroxide resulted in the formation of 2-thioester derivative [5] which was then converted to acid hydaizide derivative [6] by the reaction with hydrazine hydrate in ethanol .The reaction of hydrazide with carbon disulfide in alcoholic potassium hydroxide afforded 2 [5 (4 -(P methoxyphenyl ) azophenyl ) -1,3,4 – oxadizol2 -yl methylthio ] 1,3,4 oxadiazole -5thiol [7] . the latter was treated with propargyl bromide in basic media to give (5propynyl)thio derivative [ 8 ] which was then treated with formaldehyde and piperidine to give5-(4-piperidino)butynylthio derivative[9]. Compound [7] was also treated with n-butyl chloride in basic media to give 5 thioalkyl derivative [ 10 ] which was then oxidized with potassium permanganate in acidic media to give 5-sulfonylalkyl derivative [11]. The structures of the sythesised compounds were confirmed by melting points ,FT-IR spectra as well as elemental microanalysis. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.iasj.net/iasj?aId=50713&func=fulltext |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
