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Synthesis of Some New Schiff Bases , Tetrazole and 1 , 3-Oxazepine Derivatives Containing Azo Group and 1 , 3 , 4-Thiadiazole Moiety
| Content Provider | Semantic Scholar |
|---|---|
| Author | Abood, Zaid Hassan Haiwal, Rahman Tama |
| Copyright Year | 2014 |
| Abstract | 181 Synthesis of Some New Schiff Bases, Tetrazole and 1,3-Oxazepine Derivatives Containing Azo Group and 1,3,4Thiadiazole Moiety Zaid Hassan Abood Rahman Tama Haiwal Chemistry Department ,College of Science ,University of Kerbala Hasan Thamer ghanim Chemistry Department ,College of Education for women , University of Kufa Sajid Maqsad Radhi Chemistry Department ,College of Science ,University of Kerbala Abstract In this research new Schiff bases [5-6], tetrazole [9] and [12] and 1,3-oxazepine [7-8] and [1011] derivatives were prepared starting from azoaldehyde derivative 5,5'-(biphenyl-4,4'-diylbis(diazene2,1-diyl))bis(2-hydroxybenzaldehyde) [1] and the primary amines 5-(butylthio)-1,3,4-thiadiazol-2amine[3] and 5-(benzylthio)-1,3,4-thiadiazol-2-amine[4]. Azo aldehyde derivative[1] was prepared via coupling reaction between o-Hydroxy benzaldehyde and diazonium salt which was formed via reaction of benzidine with concentrated hydrochloric acid and sodium nitrite . The primary amines [3] and [4] were prepared by reaction of each n-butyl bromide and benzyl chloride ,respectively ,with 5-Amino-1,3,4-thiadiazole-2-thiol [2] in dry dioxane in presence of potassium hydroxide .5-Amino-1,3,4-thiadiazole-2-thiol [2] was prepared by reaction of thiosemicarbazide with carbon disulfide in presence of anhydrous sodium carbonate in absolute ethanol.The new Schiff bases [5] and [6] were prepared by reaction of azo aldehyde derivative [1] with each prepared primary amines[3] and[4],respectively , in presence of glacial acetic acid as catalyst , The new 1,3-oxazepine derivatives [7] , [8] and [10], [11] were obtained from treatment of each prepared Schiff bases derivatives [5] and [6] with each maleic anhydride and phthalic anhydride , respectively ,in dry benzene .Treatment of each prepared Schiff bases [5] and [6] with sodium azide in dry dioxane resulted the formation of new tetrazole derivatives [9] and [12] ,respectively .These new synthesized derivatives might have some biological activity. All new derivatives were characterized by melting points and are uncorrected ,(C.H.N.) elementary analysis and FT-IR spectra. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.uobjournal.com/papers/uobj_paper_2014_41318687.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
