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Localization ofα2c-adrenergic receptor immunoreactivity in catecholaminergic neurons in the rat central nervous system
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lee, Anne Wissekerke, A. E. Rosin, Diane L. Lynch, Kevin R. |
| Copyright Year | 1998 |
| Abstract | Abstract Given the importance of α 2 -adrenergic receptors in the regulation of catecholaminergic transmission, we analysed the distribution of immunoreactivity corresponding to the C-subtype of α 2 -adrenergic receptor in central catecholaminergic neurons using double-label immunohistochemistry with antibodies directed against a,c-adrenergic receptors and tyrosine hydroxylase. Cells exhibiting both α 2c -adrenergic receptor and tyrosine hydroxylase immunoreactivity were found in most areas containing catecholaminergic cell groups. However, the percentage of double-labelled cells varied in a region-specific manner. In the medulla, α 2c -adrenergic receptor immunoreactivity was characteristic of only a minority of cells exhibiting tyrosine hydroxylase immunoreactivity (40–43% in area A1/C1, 27–36% in area A2/C2, 35% in area C3) while a larger percentage of double-labelled cells was observed in the pons (65% in A5, 92% in locus coeruleus, 68% in A7). In the midbrain, α 2c -adrenergic receptor immunoreactivity was detected in most tyrosine hydroxylase-immunoreactive cells in dopaminergic regions (63% in the retrorubral field, 77–83% in substantia nigra, 67% in ventral tegmental area). These results suggest that α 2c -adrenergic receptors may act as autoreceptors on some central adrenergic and noradrenergic neurons. In addition, the colocalization of α 2c -adrenergic receptor and tyrosine hydroxylase immunoreactivity in dopaminergic cell groups suggests that reported effects of α 2 -adrenergic receptor agonists in these areas may be mediated by the C-subtype. |
| Starting Page | 1085 |
| Ending Page | 1096 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0306-4522(97)00578-2 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0306452297005782 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0306452297005782?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0306-4522%2897%2900578-2 |
| Volume Number | 84 |
| Journal | Neuroscience |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
