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Charting of Type II glucocorticoid receptor-like immunoreactivity in the rat central nervous system
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ahima, Rexford S. Harlan, Richard E. |
| Copyright Year | 1990 |
| Abstract | The rat brain and spinal cord have been mapped for Type II glucocorticoid receptor-like immunoreactivity in neurons and glia, using a monoclonal antibody, BUGR2, which recognizes an epitope close to the DNA-binding domain of the rat Type II receptor. The study revealed a widespread distribution of Type II-like immunoreactive neurons and glia, and a heterogeneity of densities and intensities of immunoreactive elements. Our results corresponded to a large extent with previous immunocytochemical mapping using Ig2a, a monoclonal antibody against a different epitope in the variable domain, with some notable differences in the hippocampus, hypothalamus and cerebellum. There was also a good correlation between immunocytochemical mapping and binding studies, [3H]steroid autoradiography and mRNA localization of the Type II receptor. |
| Starting Page | 579 |
| Ending Page | 604 |
| Page Count | 26 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0306-4522(90)90244-X |
| PubMed reference number | 1711170 |
| Journal | Medline |
| Volume Number | 39 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/030645229090244X |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/030645229090244X?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0306-4522%2890%2990244-X |
| Journal | Neuroscience |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
