NDLI: miR-199b-5p serves as a tumor suppressor in renal cell carcinoma

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miR-199b-5p serves as a tumor suppressor in renal cell carcinoma

Content Provider	Semantic Scholar
Author	Lai, Yulin Quan, Jing Lin, Canbin Li, Haitao Hu, Jia Yuan Chen, Peijie Xu, Jinling Guan, Xin Xu, Weijie Lai, Yongqing Ni, Liangchao
Copyright Year	2018
Abstract	MicroRNA (miR)-199b-5p has been reported to have a critical role in various types of malignancy. However, the exact function miR-199b-5p in renal cancer remains to be fully elucidated. The present study aimed to detect the expression levels of miR-199b-5p in renal cell carcinoma (RCC) tissues and RCC cell lines, and investigated the effect of miR-199b-5p in vitro with Cell Counting Kit-8, MTT, scratch wound, Transwell and flow cytometric assays. The results demonstrated that the expression levels of miR-199b-5p were significantly downregulated in RCC tissues and cell lines compared with those in paired adjacent normal renal tissues and a reference cell line, respectively. Downregulation of miR-199b-5p by transfection with a synthetic inhibitor promoted cellular proliferation and migration, while reducing the apoptotic rate, indicating that miR-199b-5p may serve as a tumor suppressor in RCC. Further study is required to identify target genes of miR-199b-5p to elucidate the mechanisms underlying the role of miR-199b-5p in the occurrence and development of RCC.
Starting Page	1561
Ending Page	1561
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.spandidos-publications.com/etm/16/2/1561/download
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/a3/etm-16-02-1561.PMC6099523.pdf
PubMed reference number	29896270v1
Alternate Webpage(s)	https://doi.org/10.3892/etm.2018.6151
DOI	10.3892/etm.2018.6151
Journal	Experimental and therapeutic medicine
Volume Number	16
Language	English
Access Restriction	Open
Subject Keyword	Body tissue Cell Proliferation Cultured Cell Line Epithelial cell of renal tubule Kidney Neoplasm Mast/Stem Cell Growth Factor Receptor Kit, human MicroRNAs Neoplasms Renal Cell Carcinoma Tumor Suppressor Genes monooxyethylene trimethylolpropane tristearate
Content Type	Text
Resource Type	Article

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