Loading...
Please wait, while we are loading the content...
Similar Documents
Bullous pemphigoid associated with chronic hepatitis C virus infection in a hepatitis B virus endemic area
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jang, Hyunil Jin, Young-Joo Yoon, Chang Hwi Kim, C. Kim, Lucia Choe |
| Copyright Year | 2018 |
| Abstract | INTRODUCTION Bullous pemphigoid is a type of acute or chronic autoimmune disease that involves subepidermal skin lesions with bulla formation. Although viral infections, such as, human herpes virus (HHV), human immunodeficiency virus, cytomegalovirus, Epstein-Barr virus, HHV-6, hepatitis B virus (HBV), and hepatitis C virus (HCV), are known factors of bullous pemphigoid, HCV infection has only been rarely associated factor, especially in HBV endemic area. A 78-year-old man was admitted to our hospital due to erythematous bulla of onset 3 months before presentation affecting his entire body. Pathologic findings, that is, subepidermal bullae containing eosinophils and neutrophils with superficial perivascular lymphocytic and eosinophilic infiltration, were consistent with bullous pemphigoid. Anti-HCV was positive and HCV quantitative real-time polymerase chain reaction (PCR) was 1.25 x 10 IU/mL. HCV genotype was 2a. After a diagnosis of bullous pemphigoid associated with chronic HCV infection was reached, he was treated with oral methylprednisolone for bullous pemphigoid, and his skin lesions improved. Oral direct-acting antiviral agents (sofosbuvir plus ribavirin) were prescribed for chronic hepatitis C, and sustained viral response was achieved. CONCLUSION The authors report a rare case of bullous pemphigoid associated with chronic HCV infection in a HBV endemic area and advise that HCV should be considered in the differential diagnosis of factors precipitating bullous pemphigoid, even in HBV endemic areas. |
| Starting Page | 1177 |
| Ending Page | 1178 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/cd/medi-97-e0377.PMC5908609.pdf |
| PubMed reference number | 29642192 |
| Alternate Webpage(s) | https://doi.org/10.1097/MD.0000000000010377 |
| DOI | 10.1097/MD.0000000000010377 |
| Journal | Medicine |
| Volume Number | 97 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antiviral Agents Autoimmune Diseases Bulla Bullous pemphigoid Chemical and Drug Induced Liver Injury Eosinophilic Granuloma Epstein-Barr Virus Erythema HIV Infections Hepatitis A Hepatitis B Virus Hepatitis C Virus Infection Hepatitis C, Chronic Hepatitis, Chronic Herpesviridae Herpesvirus 1, Cercopithecine Herpesvirus 6, Human Hospital admission Human herpes simplex virus Immunologic Deficiency Syndromes Methylprednisolone Reverse Transcriptase Polymerase Chain Reaction Ribavirin Virus Diseases sofosbuvir |
| Content Type | Text |
| Resource Type | Article |
