NDLI: Ribavirin derivatives with a hexitol moiety: synthesis and antiviral evaluation.

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Ribavirin derivatives with a hexitol moiety: synthesis and antiviral evaluation.

Content Provider	Semantic Scholar
Author	Aerschot, Arthur Van Schepers, Guy Busson, Roger Rozenski, Jef Neyts, Johan Clercq, Erik De Herdewijn, Piet
Copyright Year	2003
Abstract	Current standard therapy for the treatment of chronic infections with hepatitis C virus consists of combination therapy with (pegylated) interferon-alpha and ribavirin. 1,5-Anhydrohexitol nucleoside analogues are constrained congeners known to mimic the ribonucleoside conformation. Within this series some analogues are endowed with strong antiviral properties, particularly against herpesviruses. The six-membered anhydrohexitol ring was, therefore, combined with the triazolyl carboxamide moiety of ribavirin, thus providing a new series of ribavirin analogues. None of the newly synthesized compounds elicited any substantial antiviral activity, neither against herpes simplex virus type 1 and 2, nor against bovine viral diarrhoea virus (a surrogate for hepatitis C virus) or the yellow fever virus.
Starting Page	23
Ending Page	30
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.intmedpress.com/serveFile.cfm?sUID=d8130a90-3066-4354-ba2d-183c32a077cc
PubMed reference number	12790513v1
Volume Number	14
Issue Number	1
Journal	Antiviral chemistry & chemotherapy
Language	English
Access Restriction	Open
Subject Keyword	Antiviral Agents Cattle Chemical and Drug Induced Liver Injury Dacarbazine Diarrhea Hepatitis C virus Hepatitis C, Chronic Herpes Simplex Infections Herpesviridae Human herpesvirus 1 Interferon-alpha Nucleosides Recombinant Interferon-gamma Ribavirin Ribonucleosides Yellow fever virus chronic infection fagomine hexitol viral gastroenteritis
Content Type	Text
Resource Type	Article

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