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Universidade Federal Do Rio Grande Do Sul Faculdade De Veterinária Programa De Pós-graduação Em Ciências Veterinárias
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bisol, João Francisco Weber |
| Copyright Year | 2007 |
| Abstract | Rangelia vitalii is a piroplasma of the Babesia genus that belongs to Apicomplexa phylum, Sporozoasida class, and Piroplasmorida order, that causes in dogs a disease, characterized by hemolytic and hemorrhagic disorder, known as rangeliosis since the early twentieth century. The aim of this work is to describe the epidemiological characterization, analyze pathological and hematological findings, in addition to molecular detection and genetic sequencing of cases of rangeliosis in canines diagnosed in the Sector of Veterinary Pathology of the Federal University of Rio Grande do Sul. We evaluated 55 dogs diagnosed with rangeliosis between January 2004 to December 2015. Of these, 49 were diagnosed through necropsy and histological analysis, and 7 cases through molecular analysis by PCR and genetic sequencing of blood sample. The main gross lesions were characterized by generalized jaundiced, splenomegaly, hepatomegaly, lymphadenopathy, and in some cases enlarged tonsils. Various degrees of hemorrhage were observed in the mucosa of stomach, small intestine, large intestine, kidneys, lungs, and heart. Histological analysis was compatible with R. vitalii within the cytoplasm of endothelial cells of blood capillaries, especially in the heart, lungs, kidneys, small intestine, lymph nodes, spleen, and pancreas. Inflammation was predominantly mononuclear, most of which was characterized by the presence of plasma cells, and the main affected organs were kidney, stomach, heart, and lungs. The major hepatic lesions were mononuclear inflammation, cholestasis, erythrophagocytosis, paracentral necrosis, and extramedullary hematopoiesis. In spleen of most dogs was observed extramedullary hematopoiesis and erythrophagocytosis, and in lymph nodes were observed lymphoid rarefaction and erythrophagocytosis. In the bone marrow, erythroid lineage hyperplasia was the most commonly observed alteration. By analyzing the hematological findings of 17 dogs, it was noted that all patients had thrombocytopenia, and 15 animals had hypochromic macrocytic anemia. Another objective is to report the diagnosis of rangeliosis in two wild canids, a crabeating fox (Cerdocyon thous) and a Pampas fox (Lycalopex gymnocercus). On gross examination, both had paleness, slight splenomegaly and lymphadenopathy, and noticeable acinar pattern. The structures compatible with R. Vitalii were observed in the cytoplasm of endothelial cells of liver, stomach, heart, kidney, lungs, lymph glands, and bladder. The agent was characterized by PCR and genetic sequencing of liver and tick samples. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.lume.ufrgs.br/bitstream/handle/10183/202432/001006757.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://www.lume.ufrgs.br/bitstream/handle/10183/48964/000829594.pdf?sequence=1 |
| Alternate Webpage(s) | https://www.lume.ufrgs.br/bitstream/handle/10183/6300/000528197.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://www.lume.ufrgs.br/bitstream/handle/10183/206753/000969112.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://www.lume.ufrgs.br/bitstream/handle/10183/75661/000891580.pdf?isAllowed=y&sequence=1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
