NDLI: Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis

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Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis

Content Provider	Semantic Scholar
Author	Schaer, Dominik J. Schaer, C. A. Schoedon, Gabriele Imhof, Alexander Kurrer, Michael Odo
Copyright Year	2006
Abstract	OBJECTIVES Uncontrolled macrophage activation with hemophagocytosis is a distinctive feature of hemophagocytic syndromes (HPS). We examined whether lympho-histiocytic infiltration of the bone marrow and liver, as well as hemo-/erythrophagocytosis also occurs during sepsis and whether this process could account for the increased production of anti-inflammatory heme-oxygenase (HO-1) products observed during sepsis. METHODS Hemophagocytosis and expression of CD163, HO-1, ferritin as well as CD8 and granzyme-B were examined in post-mortem bone marrow samples from 28 patients with sepsis and from eight control patients. RESULTS Comparison of samples from non-septic patients with samples from patients with fatal sepsis revealed that the latter group displayed dense lympho-histiocytic bone marrow infiltration with CD163(+)/HO-1(+)/ferritin(+) macrophages as well as with CD8(+) and granzyme-B(+) T-cells. Hemophagocytosis with prominent phagocytosis of erythroid cells was readily apparent in septic patients, implying that this process is a likely stimulus for the up-regulation of macrophage HO-1 expression. CONCLUSIONS Lympho-histiocytic activation with hemophagocytosis is a shared pathophysiologic mechanism in HPS and sepsis. Furthermore, the association of hemophagocytosis with an increase in HO-1 expression may indicate a novel role for this apparently futile process as a negative regulator of inflammation.
Starting Page	432
Ending Page	436
Page Count	5
File Format	PDF HTM / HTML
PubMed reference number	17044836
Volume Number	77
Journal	European journal of haematology
Language	English
Access Restriction	Open
Subject Keyword	Anatomical compartments Anti-Inflammatory Agents Bone Marrow Granzymes Heme Oxygenase (Decyclizing) Hemophagocytic Syndrome Hermanski-Pudlak Syndrome Histiocytosis haematophagic Macrophage Activation Patients Prostaglandin-Endoperoxide Synthase Sepsis
Content Type	Text
Resource Type	Article

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