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Role of long-chain fatty acids in the postnatal induction of genes coding for liver mitochondrial beta-oxidative enzymes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pegorier, J. P. Chatelain, Francois Thumelin, Stéphane Girard, Jean |
| Copyright Year | 1998 |
| Abstract | Introduction The regulation of specific gene expression in response to changes in nutrition has become a major aspect of modern nutrition, due to the development of molecular biological techniques that have allowed the cloning of a number of genes involved in the regulation of carbohydrate and fat metabolism. It has been shown that major (glucose, fatty acids, amino acids) or minor (iron, vitamins) dietary constituents participate, in concert with many hormones, in the regulation of gene expression in response to nutritional changes (reviewed in [ 11) . This report is focused on the fetal-neonatal transition during which dramatic nutritional changes occur spontaneously and during which enzymes catalysing rate-limiting steps of fatty acid oxidation increase in the liver. The perinatal period is attended by marked changes in the nutritional environment. In utero, the fetus is continuously supplied through the placenta with a diet rich in carbohydrates and amino acids and poor in fat (reviewed in [l]). Immediately after birth, the maternal supply of substrates ceases abruptly, and the newborn has to withstand a brief period of starvation before he is fed at intervals with milk which is a high fat (60% energy) and low carbohydrate (10% energy) diet. T o meet the energy needs of the newborn, the capacity for long-chain fatty acid (LCFA) oxidation increases rapidly in many tissues (liver, heart, skeletal muscles, lung, kidney cortex, small intestine, brown adipose tissue). In the liver, the increased oxidation of LCFA results in an enhanced rate of ketone body production. In the mammalian liver, fatty acid oxidation can occur both in mitochondria and peroxisomes. During the last decade, the role and importance |
| Starting Page | 337 |
| Ending Page | 342 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.biochemsoctrans.org/content/ppbiost/26/2/113.full.pdf |
| PubMed reference number | 9649730v1 |
| Volume Number | 26 |
| Issue Number | 2 |
| Journal | Biochemical Society transactions |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adipose tissue Amino Acids Body tissue Brown Fat Carbohydrate nutrients Carbohydrates FAT1 gene Fatty Acids Fatty Liver Fatty acid glycerol esters Fetal Tissue Gene Expression Regulation Glucose Infant, Newborn Ketone Bodies Ketones Lipid Metabolism Mammals Milk (body substance) Mitochondria Mitochondrial Inheritance Platelet Glycoprotein 4, human Providing (action) Skeletal muscle structure Small Intestinal Wall Tissue Structure of cortex of kidney Structure of parenchyma of lung Uterus fatty acid oxidation peroxisome |
| Content Type | Text |
| Resource Type | Article |
