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Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chess, David J. Stanley, William |
| Copyright Year | 2007 |
| Abstract | Currently, a high carbohydrate/low fat diet is recommended for patients with hypertension; however, the potentially important role that the composition of dietary fat and carbohydrate plays in hypertension and the development of pathological left ventricular hypertrophy (LVH) has not been well characterized. Recent studies demonstrate that LVH can also be triggered by activation of insulin signaling pathways, altered adipokine levels, or the activity of peroxisome proliferator-activated receptors (PPARs), suggesting that metabolic alterations play a role in the pathophysiology of LVH. Hypertensive patients with high plasma insulin or metabolic syndrome have a greater occurrence of LVH, which could be due to insulin activation of the serine-threonine kinase Akt and its downstream targets in the heart, resulting in cellular hypertrophy. PPARs also activate cardiac gene expression and growth and are stimulated by fatty acids and consumption of a high fat diet. Dietary intake of fats and carbohydrate and the resultant effects of plasma insulin, adipokine, and lipid concentrations may affect cardiomyocyte size and function, particularly in the setting of chronic hypertension. This review discusses potential mechanisms by which dietary carbohydrates and fats ca affect cardiac growth, metabolism, and function, mainly in the context of pressure overload-induced LVH. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://cardiovascres.oxfordjournals.org/content/73/2/257.full.pdf |
| PubMed reference number | 17166490v1 |
| Volume Number | 73 |
| Issue Number | 2 |
| Journal | Cardiovascular research |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Activation action Adipokines Carbohydrate nutrients Carbohydrates Diet, High-Fat Dietary Carbohydrates Dietary Fats Fat-Restricted Diet Fatty Acids Fatty acid glycerol esters Fish Oils Gene Expression Hypertensive disease Left Ventricular Hypertrophy Lipids Metabolic Process, Cellular Metabolic Syndrome X Myocytes, Cardiac Patients Peroxisome Proliferator-Activated Receptors Peroxisome Proliferators Platelet Glycoprotein 4, human Polyunsaturated Fatty Acids Protein-Serine-Threonine Kinases Proto-Oncogene Proteins c-akt Threonine Ventricular Remodeling |
| Content Type | Text |
| Resource Type | Article |
