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Low serum levels of short-chain fatty acids after lactulose ingestion may indicate impaired colonic fermentation in patients with irritable bowel syndrome
| Content Provider | Semantic Scholar |
|---|---|
| Author | Undseth, Ragnhild Jakobsdottir, Greta Nyman, Margareta Berstad, Arnold Valeur, Jørgen |
| Copyright Year | 2015 |
| Abstract | BACKGROUND Ingestion of low-digestible carbohydrates triggers symptoms in patients with irritable bowel syndrome (IBS). These carbohydrates become substrates for microbial fermentation in the colon, yielding short-chain fatty acids (SCFAs) that are readily absorbed. Aiming to compare colonic fermentation in patients with IBS and healthy controls, we analyzed the concentrations of SCFA in serum at fasting and 90 minutes following ingestion of an unabsorbable, but fermentable carbohydrate, lactulose. METHODS Patients with IBS according to Rome III criteria (n=22) and healthy controls (n=20) ingested 10 g lactulose dissolved in water. Symptoms were graded by questionnaires and SCFA were analyzed using hollow fiber-supported liquid membrane extraction coupled with gas chromatography. RESULTS Lactulose induced more symptoms in patients with IBS than in healthy controls (P=0.0001). Fasting serum levels of SCFA did not differ between patients with IBS and controls. However, the postprandial levels of total SCFA (P=0.0002), acetic acid (P=0.005), propionic acid (P=0.0001), and butyric acid (P=0.01) were significantly lower in patients with IBS compared with healthy controls. There was no correlation between the levels of serum SCFA and symptom severity. CONCLUSION Low-serum levels of SCFA after lactulose ingestion may indicate impaired colonic fermentation in patients with IBS. Conceivably, this disturbance is related to symptom generation, but the mechanism is not clear. |
| Starting Page | 303 |
| Ending Page | 308 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.dovepress.com/getfile.php?fileID=28168 |
| Alternate Webpage(s) | https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/53/ceg-8-303.PMC4669038.pdf |
| PubMed reference number | 4669038 |
| Alternate Webpage(s) | https://doi.org/10.2147/CEG.S94084 |
| DOI | 10.2147/ceg.s94084 |
| Journal | Clinical and experimental gastroenterology |
| Volume Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acetic Acid Butyric Acids Carbohydrate nutrients Carbohydrates Colon structure (body structure) Fatty Acids Fatty Acids, Volatile Fermentation Flatulence Hollow Fiber Device Component Ingestion Intestines Irritable Bowel Syndrome Lactulose Low sodium diet Patients Precipitating Factors Propionic acid Tissue membrane |
| Content Type | Text |
| Resource Type | Article |
