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Synchronous Calcium Induced Calcium Release (CICR) in a Multiple Site Model of the Cardiac myocyte
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wallace, Dorothy I. Tanenbaum, Joseph E. |
| Copyright Year | 2013 |
| Abstract | The behavior of the muscle of the heart depends upon changes in free Ca concentration in the sarcoplasm and cytoplasm of a ventricular myocyte. We present a model of the free Ca concentration across twenty components: ten adjacent sarcoplasmic/cytoplasmic junctions. It incorporates diffusion both in the cytoplasm and the sarcoplasmic reticulum. The model shows qualitative agreement with experimental observations on the effects of altering the rate of calcium input to a cell, the efficiency of the SERCA pump, the threshold setting for CICR, and the rate of a cells calcium loss. In addition it displays spontaneous recurring calcium peaks in the presence of sufficient extracellular calcium, and these peaks are seen to synchronize across the junctions. The model confirms the importance the SR by demonstrating that this robust synchronization across sites does not occur in the absence of SR diffusion. |
| Starting Page | 115 |
| Ending Page | 131 |
| Page Count | 17 |
| File Format | PDF HTM / HTML |
| DOI | 10.1142/9789814520829_0007 |
| Alternate Webpage(s) | https://math.dartmouth.edu/~dwallace/papers/WallaceTanenbaum.pdf |
| Alternate Webpage(s) | https://doi.org/10.1142/9789814520829_0007 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |