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Prolactin response to low-dose haloperidol challenge in schizophrenic, non-schizophrenic psychotic, and control subjects
| Content Provider | Semantic Scholar |
|---|---|
| Author | Copolov, David L. Keks, Nicholas A. Kulkarni, Jayashri Singh, Bruce S. Hill, Christine |
| Copyright Year | 1990 |
| Abstract | Haloperidol was administered IV to 46 male psychotic inpatients and 28 male control subjects. A two-way analysis of covariance, with age as the covariate, revealed that DSM-III schizophrenics (n = 27) had a lower prolactin response to haloperidol than did the controls (n = 28). There were no significant differences between the prolactin responses in schizophrenics, patients with affective disorders (n = 7), and those with other psychoses (n = 12), which included patients with paranoia, schizophreniform, schizoaffective disorder, and atypical psychoses. These findings support the proposition that tuberoinfundibular dopaminergic dysfunction may occur in certain patients with DSM-III schizophrenia. |
| Starting Page | 225 |
| Ending Page | 231 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0306-4530(90)90033-6 |
| PubMed reference number | 2255750 |
| Journal | Medline |
| Volume Number | 15 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0306453090900336 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0306453090900336?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0306-4530%2890%2990033-6 |
| Journal | Psychoneuroendocrinology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
