Treatment of acute and transient psychotic disorders with low and high doses of oral haloperidol.

Content Provider	Europe PMC
Author	Khanna, Apurv Lal, Narottam Dalal, P.K. Khalid, Abdul Trivedi, J.K.
Copyright Year	1997
Abstract	The apparent rationale for the popular use of high doses of neuroleptics in psychotic patients is to increase the degree and speed of therapeutic response .However, several recent reports have questioned these claims. The present study was undertaken with the aim to compare the efficacy of high and low oral doses of haloperidol in the treatment of acute and transient psychotic disorders. The sample comprised of forty patients of both sexes diagnosed as acute and transient psychotic disorder who were randomly assigned to high dose (20 mg/day) and low dose (5 mg /day) haloperidol groups with equal number of subjects (n=20) in both groups. Weekly assessment was done on Brief Psychiatric Rating Scale and Haloperidol Side-effects Check List (day 7, 14, 21, 28, 35 & 42). Both groups showed significant improvement in BPRS from baseline scores on all assessments. Comparison of the improvement rate in both study groups revealed no significant difference.
ISSN	00195545
Volume Number	39
PubMed Central reference number	PMC2967098
Issue Number	2
PubMed reference number	21584060
Journal	Indian Journal of Psychiatry [Indian J Psychiatry]
e-ISSN	19983794
Language	English
Publisher	Medknow Publications
Publisher Date	1997-04-01
Publisher Place	India
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright: © Indian Journal of Psychiatry
Subject Keyword	Oral haloperidol low dose high dose acute and transient psychotic disorders
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health