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N-Heterocyclic carbene-catalyzed [4 + 2] cyclization of α,β-unsaturated carboxylic acids bearing γ-H with isatins: an enantioselective synthesis of spirocyclic oxindole-dihydropyranones.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhu, Ling Yu, Chenxia Li, Tuanjie Wang, Yuhong Lu, Yinan Wang, Wen-Jing Yao, Changsheng |
| Copyright Year | 2016 |
| Abstract | An NHC-catalyzed asymmetric [4 + 2] annulation of isatins and α,β-unsaturated carboxylic acids bearing γ-H gave spirocyclic oxindole-dihydropyranones successfully via an in situ activation strategy. This protocol featured easy availability of raw materials, good yields and excellent enantioselectivities (up to 99% ee). |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c5ob02160j |
| PubMed reference number | 26690686 |
| Journal | Medline |
| Volume Number | 14 |
| Issue Number | 4 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c5/ob/c5ob02160j/c5ob02160j1.pdf |
| Alternate Webpage(s) | https://pubs.rsc.org/en/content/getauthorversionpdf/C5OB02160J |
| Alternate Webpage(s) | https://doi.org/10.1039/c5ob02160j |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |