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NHC-catalyzed oxidative γ-addition of α,β-unsaturated aldehydes to isatins: a high-efficiency synthesis of spirocyclic oxindole-dihydropyranones.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yu, Chenxia Xiao, Zhaoxin Li, Tuanjie Wang, Xiangshan Xie, Yuanwei Yao, Changsheng |
| Copyright Year | 2014 |
| Abstract | This manuscript discloses an efficient construction of the spirocyclic oxindole-dihydropyranone scaffold via the N-heterocyclic carbene (NHC)-catalyzed oxidative γ-functionalization of α,β-unsaturated aldehydes bearing γ-H with isatin derivatives. The ready availability of the starting materials, easy work-up, mild reaction conditions and the potential utilization value of the products make this strategy attractive. |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c3ob42008f |
| PubMed reference number | 24518966 |
| Journal | Medline |
| Volume Number | 12 |
| Issue Number | 12 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/ob/c3/c3ob42008f/c3ob42008f1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c3ob42008f |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |