NDLI: Antiinflammatory activity of astilbic acid from Astilbe chinensis.

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Antiinflammatory activity of astilbic acid from Astilbe chinensis.

Content Provider	Semantic Scholar
Author	Moon, Tae Chul Lin, Chang Xiu Lee, Joo Sang Kim, Dong Seon Bae, Kihwan Son, Kun Ho Kim, Hyun Pyo Kang, Sam Sik Son, Jong Keun Chang, Hyeun Wook
Copyright Year	2005
Abstract	This study examined the effect of astilbic acid (3beta,6beta-dihydroxyolean-12-en-27-oic acid), which is a herbal medicine isolated from Astilbe chinensis. Astilbic acid inhibited 5-lipoxygenase (5-LOX)-dependent leukotriene C4 (LTC4) generation in bone marrow-derived mast cells in a concentration-dependent manner with an IC50 value of 2.1 microM. In addition, astilbic acid was tested in a rat passive cutaneous anaphylaxis (PCA) reaction assay by administering 10 to 50 mg/kg i.p. Astilbic acid dose dependently inhibited the PCA reaction, which was activated by anti-dinitrophenyl (DNP) IgE. Furthermore, this compound inhibited mouse acetic acid-induced writhing (47-62% inhibition at 0.4-50 mg/kg) after being administered orally, while aspirin (200 mg/kg) showed 62% inhibition. These results suggest that astilbic acid may be beneficial in regulating various inflammatory processes.
Starting Page	295
Ending Page	300
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/bpb/28/1/28_1_24/_pdf
PubMed reference number	15635157v1
Volume Number	28
Issue Number	1
Journal	Biological & pharmaceutical bulletin
Language	English
Access Restriction	Open
Subject Keyword	2,4-Dinitrophenol Acetic Acid Administration procedure Arachidonate 5-Lipoxygenase Aspirin Astilbe chinensis Bone Marrow Inhibitory Concentration 50 Leukotriene Antagonists Leukotriene C4 Leukotrienes Oral cavity Passive Cutaneous Anaphylaxis Thioctic Acid dinitrophenyl mast cell mg/kg p-Chloroamphetamine
Content Type	Text
Resource Type	Article

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