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Allergenicity and Cross-Reactivity of 3 House Dust Mite Species Among Filipino Allergic Patients
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ramos, John Donnie A. Castillo, M. Rosario, Michelle Del Gapay, Michelle Ann Sheela Go, Tristan Perryn Kamantigue, E. |
| Copyright Year | 2008 |
| Abstract | The immunoglobulin E-binding activity of allergens from the house dust mite (HDM) Blomia tropicalis (Bt), Dermatophagoides farinae (Df), and Dermatopahagoides pteronyssinus (Dp) were determined using a panel of 210 allergic and 85 non-atopic Filipino subjects. Enzyme-linked immunosorbent assay showed that 91%, 89%, and 86% of Filipino allergic subjects tested are sensitized with Bt, Df, and Dp allergens, respectively. Western Blot Analysis identified multiple IgE reactivities of selected patients’ sera to HDM proteins with molecular weight ranging from 10–80 kDA. Absorption assays by inhibition ELISA showed that up to 60% inhibition can be detected between the three HDM species. The results obtained in this study suggest that Bt, Dp, and Df are important HDM species in the local population causing sensitization in the majority of allergic Filipino patients tested. The incorporation of Bt, Dp, and Df allergens in the panel of diagnostic allergens for HDM allergy are highly recommended. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://philjournalsci.dost.gov.ph/images/pdf/pjs_pdf/vol136no2/pdfs/Allergenicity_and_Cross_Reactivity.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
